教員

ai-200-150.jpg

井上 明宏

INOUE Akihiro

職名 教授
専門分野 細胞生物学、解剖生理学
連絡先

E-mail:a-inoue@redcross.ac.jp

プロフィール

学歴 筑波大学大学院 医科学研究科 修士課程(医科学専攻) 修了
総合研究大学院大学 生命科学研究科 博士課程(生理科学専攻) 修了
学位 医科学修士(筑波大学)
博士(学術)(総合研究大学院大学)
主要職歴 東京医科歯科大学大学院 医歯学総合研究科 准教授
担当授業科目 【学部】 
 「人体の構造と機能 I」
 「人体の構造と機能 II」
 「疾病の成り立ちと回復の促進 I」
 「疾病の成り立ちと回復の促進 II」
 「疾病の成り立ちと回復の促進 III」
 「疾病の成り立ちと回復の促進 IV」
 「基礎ゼミ I」
 「基礎ゼミ II」
 「研究 I」
 「研究 II」

【大学院】
 「病態生理学」(修士)
 「人間総合講座」(修士)
研究テーマ 神経系の発生および神経細胞の形態と機能の研究
光活性化タンパク質を用いた細胞機能の研究
主要所属学会

日本解剖学会

日本神経科学学会

日本ヘルスコミュニケーション学会

主要著書・論文

1. Numano, F., Inoue, A., Enomoto, M., Shinomiya, K., Okawa, A. and Okabe, S. (2009). Critical involvement of Rho GTPase activity in the efficient transplantation of neural stem cells into the injured spinal cord. Molecular Brain, 2:37.

2. Yamagata, Y., Kobayashi, S., Umeda, T., Inoue, A., Sakagami, H., Fukaya, M., Watanabe, M., Hatanaka, N., Totsuka, M., Yagi, T., Obata, K., Imoto, K., Yanagawa, Y., Manabe, T. and Okabe, S. (2009). Kinase-dead knock-in mouse reveals an essential role of kinase activity of Ca2+/calmodulin-dependent protein kinase IIalpha in dendritic spine enlargement, long-term potentiation, and learning. Journal of Neuroscience, 29:7607-18.

3. Kuriu, T., Inoue, A., Bito, H., Sobue, K. and Okabe, S. (2006). Differential Control of Postsynaptic Density Scaffolds via Actin-Dependent and -Independent Mechanisms. Journal of Neuroscience, 26:7693-7706.

4. Iki, J., Inoue, A., Bito, H. and Okabe, S. (2005). Bi-directional regulation of postsynaptic cortactin distribution by BDNF and NMDA receptor activity. European Journal of Neuroscience, 22:2985-2994.

5. Nakazawa, T., Watabe, A.M., Tezuka, T., Yoshida, Y., Yokoyama, K., Umemori, H., Inoue, A., Okabe, S., Manabe, T. and Yamamoto, T. (2003). Molecular Biology of the Cell, 14:2921-2934.

6. Inoue, A. and Okabe, S. (2003). The dynamic organization of postsynaptic proteins: translocating molecules regulate synaptic function. Current. Opinion in Neurobiology, 13:332-340.

7. Inoue, A. and Sanes, J.R. (1997). Lamina-specific connectivity in the brain: roles for N-cadherin, neurotrophins and glycoconjugates. Science, 276: 1428-143.

8. Inoue, A., Takahashi, M., Hatta, K., Hotta, Y., and Okamoto, H. (1994). Developmental regulation of Isl-1 mRNA expression during neuronal differentiation in embryonic zebrafish. Developmental Dynamics, 199:1-11.

9. Kuwayama, H., Suzuki, M., Inoue, A., Kobayashi, H., Tanaka, H., Mikawa, T., Sugiura, M. and Ebashi, S. (1993). Amino acid sequence of myosin light chain kinase from bovine stomach with special references to its actin binding. Biomedical Research, 14:Suppl. 2, 113-116.

10. Inoue, A. and Akagawa, K. (1993). Neuron specific expression of a newly-identified cell membrane protein, HPC-1: Tissue distribution, and cellular and subcellular localization of immunoreactivity and mRNA. Molecular Brain Research, 19:121-128.

11. Kobayashi, H., Inoue, A., Mikawa, T., Kuwayama, H., Hotta, Y., Masaki, T., and Ebashi, S. (1992). Isolation of cDNA for bovine stomach 155kDa protein exhibiting myosin light chain kinase activity. Journal of. Biochemistry, 112:786-791.

12. Inoue, A. and Akagawa, K. (1992). Neuron-specific antigen HPC-1 from bovine brain reveals strong homology to epimorphin, an essential factor involved in epithelial morphogenesis: identification of a novel protein family. Biochemical and Biophysical Research Communications, 187:1144-1150.

13. Inoue, A., Obata, K. and Akagawa, K. (1992). Cloning and sequence analysis of cDNA for a neuronal cell membrane antigen, HPC-1. Journal of Biological Chemistry, 267:10613-10619.

14. Inoue, A., Yanagisawa, M. and Masaki, T. (1992). Differential tissue expression of multiple genes for smooth muscle/nonmuscle myosin light chains. Biochimica Biophysoica Acta, 1130:197-202.

15. Arinami, T., Ishikawa, M., Inoue, A., Yanagisawa, M., Masaki, T,. Yoshida, M.C. and Hamaguchi, H. (1991). American Journal of Human Genetics, 48, 990-996.

16. Masaki, T., Yanagisawa, M., Inoue, A., Kimura, S., and Goto, K. (1990). Study on the endothelin gene and its expression. Japanese Circulation Journal, 54, 1221-1225.

17. Inoue, A., Yanagisawa, M., Takano-Ohmuro, H. and Masaki, T. (1989). Two isoforms of smooth muscle myosin regulatory light chain in chicken gizzard. European Journal of. Biochemistry, 183:645-661.

18. Inoue, A., Yanagisawa, M. and Masaki, T. (1989). The human preproendothelin-1 gene: Complete nucleotide sequence and regulation of expression. Journal of Biological Chemistry, 264:25, 14954-14959.

19. Inoue, A., Yanagisawa, M., Kimura, S., Kasuya, Y., Miyauchi, T., Goto, K., and Masaki, T. (1989). The human endothelin family: Three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proceedings of National Academy of. Sciences of the USA. 86, 2863-2867.

20. Yanagisawa, M., Inoue, A., Ishikawa, T., Kasuya, Y., Kimura, S., Kumagaye, S., Nakajima, K., Watanabe, T.X., Sakakibara, S., Goto, K. and Masaki, T. (1988). Primary structure, synthesis, and biological activity of rat endothelin, an endothelium-derived vasoconstrictor peptide. Proceedings of National Academy of Sciences of the USA, 85, 6964-6967.

21. Ito, Y., Yanagisawa, M., Ohkubo, M., Kimura, C., Kosaka, T., Inoue, A., Ishida, N., Mitsui, Y., Onda, H., Fujino, M. and Masaki, T. (1988). Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: Identity of human and porcine endothelin. FEBS Letters, 231, 2, 440-444.